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Svjetlana Kireta

Svjetlana started work in the Queen Elizabeth Hosiptal Renal Transplant Immunology Laboratory in 1991, shortly after arriving to Australia. She graduated from Zagreb University in Croatia and was employed for 5 years as a Research Scientist in The Biochemistry department of a Pharmaceutical Company, then spent a year working in the Department of Biological Sciences at The University College of Wales, UK.

Over the years in our laboratory (now the CCET) Svjetlana worked on a number of projects in the field of immunobiology of transplantation. The main areas of research include adenoviral gene therapy and regulatory-T cells, dendritic cells biology in humans and animal models, and immunomodulation therapies for organ transplantation.  She has expertise in flow cytometry and may other laboratory techniques, and is responsible for trainign of new students in the laboratory. She currently works on dendritic cells and their precursors in pre-eclampsia, a serious disorder of pregnancy.

Publications: 

Hughes A, Mohanasundaram D, Kireta S, Jessup CF, Drogemuller CJ, Coates PT. Insulin-Like Growth Factor-II (IGF-II) Prevents Proinflammatory Cytokine-Induced Apoptosis and Significantly Improves Islet Survival After Transplantation. Transplantation. 2013 Mar 15;95(5):671-678.

Jesudason S, Collins MG, Rogers NM, Kireta S, Coates PT. Non-human primate dendritic cells. J Leukoc Biol. 2012 Feb; 91(2):217-28

Rogers NM, Kireta S, Coates PT.  Curcumin induces maturation-arrested   dendritic cells that expand regulatory T cells in vitro and in vivo. Clin Exp Immunol. 2010 Dec;162(3):460-73

Rogers NM, Eng HS, Yu R, Kireta S, Tsiopelas E, Bennett GD, Brook NR, Gillis D, Russ GR, Coates PT.   Desensitisation for renal transplantation: depletion of  donor-specific anti-HLA antibodies, preservation of memory antibodies and clinical risks. Transplant Int, 2011 Jan;24(1):21-9.

Prasad S, Kireta S, Leedham E, Russ GR, Coates PTH. Propagation and characterisation of dendritic cells from G-CSF mobilised peripheral blood monocytes and stem cells in common marmoset monkeys. Journal of Immunological Methods. 2010 Jan 31; 352 (1-2):59-70

Jamie L Brady, Stuart I Mannering, Svjetlana Kireta, Patrick T Coates, Anna I Proietto, Peter J Cowan, Anthony J F D'Apice, Andrew M Lew. Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates. Immunology and Cell Biology 2009; 87(5): 413-418

Lim WH, Kireta S, Leedham E, Russ GR, Coates PTH. Uraemia impairs monocytes and monocyte-derived dendritic cell function in haemodialysis patients. Kidney International 2007; 72(9): 1138-48

Prasad S, Humphreys I, Kireta S, Gilchrist RB, Bardy P, Russ GR, Coates PT. The common marmoset as a novel preclinical transplant model: identification of new MHC class II DRB alleles and prediction of in vitro alloreactivity. Tissue Antigens. 2007; Apr;69 Suppl 1: 72-5.

Lim WH, Kireta S, Russ GR, Coates PTH. Uraemia impairs blood myeloid and plasmacytoid dendritic cell function in haemodialysis patients. Kidney International 2007; 71(11): 1122-31

Lim WH, Kireta S, Russ GR, Coates PTH. Human Plasmacytoid Dendritic Cells Regulate Immune Responses To Epstein-Barr Virus (EBV) Infection Via Toll-Like Receptor-9 Signaling And Delay EBV-Related Mortality In Humanized NOD-SCID Mice. Blood 2007 Feb 1; 109(3): 1043-50.

Prasad S, Humphreys I, Kireta S, Gilchrist RB, Bardy P, Russ GR, Coates PT. MHC Class II DRB genotyping is highly predictive of in-vitro alloreactivity in the common marmoset. J Immunol Methods. 2006; Jul 31; 314(1-2): 153-63.

Lim WH, Kireta S, Thomson AW, Russ GR, Coates PT. Renal transplantation reverses functional deficiencies in circulating dendritic cell subsets in chronic renal failure patients. Transplantation. 2006; Jan 27; 81(2): 160-8.

Kireta S, Zola H, Gilchrist RB, Coates PT. Cross-reactivity of anti-human chemokine receptor and anti-TNF family antibodies with common marmoset (Callithrix jacchus) leukocytes. Cell Immunol. 2005; Jul-Aug; 236(1-2): 115-22.

Newland A, Kireta S, Russ G, Krishnan R. Ovine dendritic cells transduced with an adenoviral CTLA4eEGFP fusion protein construct induce hyporesponsiveness to allostimulation. Immunology. 2004; Nov; 113(3): 310-7.

Coates PT, Krishnan R, Kireta S, Johnston J, Russ GR. Human myeloid dendritic cells transduced with an adenoviral interleukin-10 gene construct inhibit human skin graft rejection in humanized NOD-scid chimeric mice
Gene Therapy. 2001 Aug; 8(16): 1224-33.

Coates T, Krishnan R, Chew G, Kireta S, Johnston J, Kanachanabat B, Russell CH, Siddins M, Russ GR. Dendritic cell TH2 cytokine gene therapy in sheep. Transplant Proc. 2001; Feb-Mar; 33(1-2): 180-1.

Krishnan R, Kireta S, Carter JK, Grooby WL, Rao MM, Russ GR. Expression of alternatively spliced CD44 mRNA in sheep renal allografts. Transplant Proc. 1995; Jun; 27(3): 2170-1.