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Research List

Islet Cell Transplantation

Type I diabetes is a chronic, life-long autoimmune disease affecting over 140 000 Australians, where the insulin-producing islets of Langerhans in the pancreas are destroyed. The incidence of this disease is increasing and, even with daily insulin therapy, diabetic patients are at greater risk of serious complications including heart attack, stroke, ocular damage and kidney disease.

Obstetric Nephrology and Immunology

Pregnancy Outcomes in Women with Renal Disease

Pregnancy in women with advanced chronic kidney disease, end-stage kidney disease requiring dialysis therapy or after renal transplantation is a challenging clinical scenario. These are high risk pregnancies with a high rate of maternal and fetal complications, even in women who have well-functioning kidney transplants. We are interested in better defining the maternal, obstetric and perinatal factors that affect these pregnancies, in order to improve outcomes for both mother and baby.

Cell Therapy for Transplantation

Tolerogenic dendritic cells for transplantation

Dendritic cells (DC) are the sentinels of the immune system, potently directing the immune response towards a reactive or tolerant outcome. As such, DC are vitally important following the transplantation of organs and tissues. Our group has a long history in working with DC and using them to modify the immune system.