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Cell Therapy for Transplantation

Tolerogenic dendritic cells for transplantation

Dendritic cells (DC) are the sentinels of the immune system, potently directing the immune response towards a reactive or tolerant outcome. As such, DC are vitally important following the transplantation of organs and tissues. Our group has a long history in working with DC and using them to modify the immune system.

Current projects involve modifying DC genetically or with sophisticated new methods of drug delivery to induce immune tolerance, and coadministering these DC to prevent transplant rejection.

Mesenchymal Stem Cells in Kidney Repair and Transplantation

In this project, we are exploring the therapeutic potential of ovine and human mesenchymal stem cells in kidney injury, with a particular emphasis on ischaemia reperfusion injury. Magnetic resonance imaging (MRI) is used to provide in vivo imaging of iron labelled MSC in a project supported by the Large Animal Research Imaging Facility (LARIF) in SA Pathology .