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Dr Shilpanjali Jesudason

Dr Jesudason (nee Prasad) is a nephrologist in the Central and Northern Adelaide Renal and Transplantation Service (CNARTS) at the Royal Adelaide Hospital, visiting consultant in Obstetric Medicine and Obstetric Nephrology at the Women's and Children's Hospital and Clinical Senior Lecturer, University of Adelaide. She trained at the Royal Adelaide Hospital, Flinders Medical Centre and St Mary's Hospital Transplant Unit (UK). She returned in 2004 to undertake PhD studies in transplantation immunology (dendritic cell biology) at the Queen Elizabeth Hospital. She joined the Women's and Children's team in 2010, and the Royal Adelaide Hospital team in 2011.

Her current clinical interests revolve around the theme of Obstetric Nephrology. She has expertise in the management of pregnancy-related issues in women with renal disease, including CKD, dialysis and transplant patients, and living kidney donors.  Her clinical research aims to define maternal, fetal and infant aspects of pregnancies in women with all stages of chronic kidney disease, as well as longer-term outcomes for babies of men and women with kidney failure. She oversees a broad range of research activities utilising population and registry data linkage and and epidemiological analysis, employing qualitative methods to explore patient and clinican perspectives, and is developing prospective studies to generate new evidence to inform clinical decision-making, identify gaps in care, and influence management and outcomes for this high-risk cohort. 

Her current laboratory research involves defining aspects of immune phenotype and function in normal versus pre-eclamptic pregnancies. In collaboration with colleagues Prof Toby Coates and Dr Rob Carroll, other projects include developing novel methods to target dendritic cells to modify the immune repsonse in transplantation, and new methods of evaluating the immune phenotype in transplant receipients to enable individualisation of immunosuppression in transplant recipients.

She supervises PhD and honours students, medical students and physician trainees in research projects, as well as supervising 24 basic trainees per year in CNARTS. She leads the newly established CNARTS Clinical Research Group which brings together an experienced group of medical, nursing and allied health researchers.

Publications: 

Peer Reviewed Journals:

  1. Tong A, Brown MA, Winkelmayer WC, Craig JC, Jesudason S. Perspectives on pregnancy in women with chronic kidney disease. Am J Kidney Dis [Accepted August 7th, 2015]
  1. Hope CM, Fuss A, Hanf W, Jesudason S, Coates PTH, Heeger P, Carroll R. Peripheral Blood Natural Killer Cell Function and Allo-stimulated T-Cell Interferon-γ Release in Kidney Transplant Recipients Associates with Cancer and Defines Risk of Immunosuppression Related Complications. 2015 Kidney International (epub, Aug 12 2015).
  1. Jesudason S, McDonald SP. Gestational Hypertension and Preeclampsia in Living Kidney Donors. New England Journal Of Medicine 2015: 372(15):1469-1469
  1. Tong A, Jesudason S, Craig JC, Winkelmayer WC. Perspectives on pregnancy in women with chronic kidney disease: Systematic review of qualitative studies. Nephrology Dialysis Transplantation 2015; 30(4):652-661
  1. Collins MG, Rogers NM, Jesudason S, Kireta S, Brealey J, Coates PT. Spontaneous glomerular mesangial lesions in common marmoset monkeys (Callithrix jacchus): a benign non-progressive glomerulopathy. J Med Primatol. 2014;  43(6):477-487
  1. Jesudason S, Grace B and McDonald SP. Pregnancy Outcomes According to Dialysis Commencing Before or After Conception in Women with End-stage Kidney Disease. Clinical Journal of the American Society of Nephrology 2014. 9(1): p. 143-9.
  1. Wyld M, Clayton P, Jesudason S, Chadban S, Alexander S. Pregnancy outcomes for kidney transplant recipients. American Journal of Transplantation 2013; 13(12):3173-3182
  1. Jesudason S, Collins MG, Rogers NM, Kireta S, Coates PT. Non-human primate dendritic cells. (Review) J Leukoc Biol. 2012 Feb;91(2):217-28.
  1. Prasad S, Kireta S, Leedham E, Russ GR, Coates PT. Propagation and characterisation of dendritic cells from G-CSF mobilised peripheral blood monocytes and stem cells in common marmoset monkeys. J Immunol Methods 2010; 352(1-2):59-70
  1. Prasad S, Humphreys I, Kireta S, Gilchrist RB, Bardy P, Russ GR, Coates PT. The Common Marmoset as a Novel Pre-Clinical Transplant Model: Identification Of New MHC Class II DRB Alleles And Prediction Of In-Vitro Allo-Reactivity. Tissue Antigens 2007; 69: Suppl 1:72-75
  1. Prasad S, Humphreys I, Kireta S, Gilchrist RB, Bardy P, Russ GR, Coates PT. MHC Class II DRB genotyping is highly predictive of in-vitro alloreactivity in the common marmoset. J Immunol Methods. 2006 Jul 31;314(1-2):153-63.
  1. Prasad S, Singh S, Duncan N, Cairns TD, Griffith M, Hakim N, McLean AG, Palmer A, Papalois V, Taube D. Ethnicity and survival on dialysis in west London. Kidney International. 2004 Dec;66(6):2416-21.
  1. Loucaidou M, Prasad S, Van Tromp J, Cairns TD, Griffith M, Hakim N, McLean AG, Palmer A, Papalois V, Taube D. Outcome of renal transplantation in South Asian recipients is similar to that in non-Asians. Transplantation. 2004 Oct 15;78(7):1021-4.
  1. Evans AM, Faull RJ, Nation RL, Prasad S, Elias T, Reuter SE, Fornasini G. Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease. Kidney International. 2004 Oct;66(4):1527-34.
  1. Prasad S, Parkhurst D, Morton MR, Henning P, Lawton J, Bannister K. Increased Delivery Of Haemodialysis Assists Successful Pregnancy Outcome In End-Stage Renal Failure. Nephrology 2003; 8(6):311-4
  1. Prasad S, Lee A, Clarnette R, Faull R. Spontaneous bilateral patellar tendon rupture in a woman with previous Achilles tendon rupture and systemic lupus erythematosus. Rheumatology 2003; 42(7): 905-6.
  1. Prasad S, Bannister K, Taylor J. Is magnetic resonance angiography useful in renovascular disease?  Internal Medicine Journal 2003; 33(3): 84-90
  1. Prasad S, Russ G, Faull R. Live donor renal transplantation in Australia 1964-1999: an evolving practice. Internal Medicine Journal 2002; 32(12) 569-74

Registry Report and Book Chapters:

  1. Jesudason, S and Hague W. A woman with renal impairment.  In Macklon N et al: Case Studies in Assisted Reproduction: Common & Uncommon Cases, Cambridge, Cambridge University Press, 2015.
  1. Prasad S, Faull R, Russ G. Living related kidney donors. Page 99-103. ANZDATA Registry Report 2001. Ed: Russ G. Australian and New Zealand Dialysis and Transplantation Registry, Adelaide, South Australia, 2002.

 

Research Interests: 
Obstetric Nephrology and Immunology
Cell Therapy for Transplantation